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Home - Products - GPCR/G Protein - Dopamine Receptor - Alpha-Methyldopa Sesquihydrate

Alpha-Methyldopa Sesquihydrate

CAS No. 41372-08-1

Alpha-Methyldopa Sesquihydrate( MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate )

Catalog No. M20585 CAS No. 41372-08-1

Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Alpha-Methyldopa Sesquihydrate
  • Note
    Research use only, not for human use.
  • Brief Description
    Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.
  • Description
    Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.(In Vivo):Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment.
  • In Vitro
    ——
  • In Vivo
    Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal Model:60-day-old male rats Dosage:200 mg/kg Administration: i.p.Result:Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.
  • Synonyms
    MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    DOPA decarboxylase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    41372-08-1
  • Formula Weight
    238.24
  • Molecular Formula
    C10H13NO4·3/2H?O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:33.33 mg/mL (139.90 mM)
  • SMILES
    O.O.O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O
  • Chemical Name
    (S)-2-amino-3-(34-dihydroxyphenyl)-2-methylpropanoic acid sesquihydrate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Baila M R Cintas J A . [The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension][J]. El Día Médico 1962 34:2422.
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