Alpha-Methyldopa Sesquihydrate( MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate )

Catalog No. M20585 CAS No. 41372-08-1

Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
500MG	37	In Stock
1G	43	In Stock

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Biological Information

Product Name

Alpha-Methyldopa Sesquihydrate
Note

Research use only, not for human use.
Brief Description

Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.
Description

Alpha-Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension.?It inhibits the sympathetic nervous system decreases production of dopamine norepinephrine and epinephrine and exhibits NO-dependent sedative activity.(In Vivo):Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment.
In Vitro

——
In Vivo

Methyldopa hydrate (L-(-)-α-Methyldopa hydrate; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment. Animal Model:60-day-old male rats Dosage:200 mg/kg Administration: i.p.Result:Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.
Synonyms

MK-351 hydrate | Methyldopa hydrate | Methyldopa Sesquihydrate | L-(-)-α-Methyldopa hydrate
Pathway

GPCR/G Protein
Target

Dopamine Receptor
Recptor

DOPA decarboxylase
Research Area

——
Indication

——

Chemical Information

CAS Number

41372-08-1
Formula Weight

238.24
Molecular Formula

C10H13NO4·3/2H?O
Purity

>98% (HPLC)
Solubility

DMSO:33.33 mg/mL (139.90 mM)
SMILES

O.O.O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O.C[C@](N)(Cc1ccc(O)c(O)c1)C(O)=O
Chemical Name

(S)-2-amino-3-(34-dihydroxyphenyl)-2-methylpropanoic acid sesquihydrate

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Baila M R Cintas J A . [The use of the combination of L-alpha-methyldopa and dichlorothiazide in the treatment of arterial hypertension][J]. El Día Médico 1962 34:2422.

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